| Date | Opponent | Location | Time/Result | Record/MEAC | Game Story | |
| Sep. 2 |  |
Florida A&M Ford Football Classic |
Detroit, MI | 34-14 DSU | 1-0, 1-0 | Story |
| Sep. 9 | St. Francis (Pa.) Military Appreciation Day |
Alumni Stadium | 63-28 DSU | 2-0, 1-0 | Story | |
| Sep. 16 | Northwestern State | Natchitoches, LA | 23-3 NSU | 2-1, 1-0 | Story | |
| Sep. 23 | OPEN | OPEN | ||||
| Sep. 30 | |
Hampton Communiversity Day |
Alumni Stadium | 29-14 HU | 2-2, 1-1 | Story |
| Oct. 7 | |
Bethune-Cookman | Daytona Beach, FL | 33-31 DSU | 3-2, 2-1 | Story |
| Oct. 14 | |
North Carolina A&T State Homecoming |
Alumni Stadium | 37-21 DSU | 4-2, 3-1 | Story |
| Oct. 21 | |
Morgan State | Baltimore, MD | 29-7 DSU | 5-2, 4-1 | Story |
| Oct. 28 | |
South Carolina State Youth Day |
Alumni Stadium | 10-9 DSU | 6-2, 5-1 | Story |
| Nov. 4 | Concord (WV) Family Day |
Alumni Stadium | 62-0 DSU | 7-2, 5-1 | Story | |
| Nov. 11 | |
Norfolk State | Norfolk, VA | 33-10 DSU | 8-2, 6-1 | Story |
| Nov. 18 | |
Howard | Washington, DC | 20-17 HU | 8-3, 6-2 | Story |
Indicates
MEAC game. Home games in bold.