| 2005 Composite Schedule (PDF) | ||||||
| Date | Opponent | Location | Time/Result | Record/MEAC | Game Story | |
| Sep. 03 |  |
Florida A&M | Tallahassee, FL | 21-17 DSU | 1-0, 1-0 | Game Story |
| Sep. 10 | Millersville | Alumni Stadium | 38-6 DSU | 2-0, 1-0 | Game Story | |
| Sep. 17 | James Madison | Harrisonburg, Va. | 65-7 JMU | 2-1, 1-0 | Game Story | |
| Sep. 24 | Coastal Carolina | Conway, SC | 24-6 CCU | 2-2, 1-0 | Game Story | |
| Oct. 01 | |
Hampton | Hampton, VA | 26-8 HU | 2-3, 1-1 | Game Story |
| Oct. 08 | |
Bethune-Cookman | Alumni Stadium | 17-0 DSU | 3-3, 2-1 | Game Story |
| Oct. 15 | |
North Carolina A&T State | Greensboro, NC | 23-13 DSU | 4-3, 3-1 | Game Story |
| Oct. 22 | |
Morgan State Homecoming |
Alumni Stadium | 41-14 DSU | 5-3, 4-1 | Game Story |
| Oct. 29 | |
South Carolina State | Orangeburg, SC | 24-3 SCSU | 5-4, 4-2 | Game Story |
| Nov. 12 | |
Norfolk State | Alumni Stadium | 38-17 DSU | 6-4, 5-2 | Game Story |
| Nov. 19 | |
Howard | Alumni Stadium | 23-7 DSU | 7-4, 6-2 | Game Story |
Indicates
MEAC game. Home games in bold.