| Date | Opponent | Location | Time/Result | |
| Sep. 04 | Massachusetts | Alumni Stadium | 0-51 UMass | |
| Sep. 11 | North Carolina Central | Alumni Stadium | 23-26 NCC | |
| Sep. 18 | Elon | Elon, NC | 13-49 Elon | |
| Sep. 25 | Southern Illinois | Alumni Stadium | 0-49 SIU | |
| Oct. 02 |  |
Hampton | Alumni Stadium | 28-23 DSU |
| Oct. 09 | |
Bethune-Cookman | Daytona Beach, FL | 16-45 BCC |
| Oct. 16 | |
North Carolina A&T State | Alumni Stadium | 15-6 DSU |
| Oct. 23 | |
Morgan State | Baltimore, MD | 30-34 MSU |
| Oct. 30 | |
South Carolina State Homecoming |
Alumni Stadium | 14-28 SCSU |
| Nov. 13 | |
Norfolk State | Norfolk, VA | 33-28 DSU |
| Nov. 20 | |
Howard | Washington, DC | 32-13 DSU |
Indicates
MEAC game. Home games in bold.