| Date | Opponent | Location | Time/Result | Record/MEAC | |
| Nov. 19 | Illinois | Champaign, IL | 67-87 IU | 0-1, 0-0 | |
| Nov. 21 | Las Vegas Holiday Invitational vs. Texas-El Paso |
Las Vegas, NV | 50-83 UTEP | 0-2, 0-0 | |
| Nov. 23 | Las Vegas Holiday Invitational vs. Arizona State |
Las Vegas, NV | 56-67 ASU | 0-3, 0-0 | |
| Nov. 26 | Las Vegas Holiday Invitational vs. Jackson State |
Las Vegas, NV | 71-56 DSU | 1-3, 0-0 | |
| Nov. 27 | Las Vegas Holiday Invitational Championship Round vs. Tennessee State |
Las Vegas, NV | 69-75 TSU | 1-4, 0-0 | |
| Feb. 19 |  |
MEAC Round Robin vs. South Carolina State |
Orlando, FL | 4-0 SCSU | |
| Dec. 01 | Marquette | Milwaukee, WI | 60-66 MU | 1-5, 0-0 | |
| Dec. 04 | |
Maryland-Eastern Shore | Princess Anne, MD | 65-55 DSU | 2-5, 1-0 |
| Dec. 18 | Michigan State | East Lansing, MI | 45-63 MSU | 2-6, 1-0 | |
| Dec. 20 | Jacksonville State | Memorial Hall | 66-64 DSU | 3-6, 1-0 | |
| Dec. 22 | Murray State | Murray, KY | 39-68 MSU | 3-7, 1-0 | |
| Dec. 27 | Northwestern | Evanston, IL | 43-50 NU | 3-8, 1-0 | |
| Dec. 29 | Michigan | Ann Arbor, MI | 48-66 UM | 3-9, 1-0 | |
| Jan. 08 | |
Coppin State | Memorial Hall | 56-63 CSU | 3-10, 1-1 |
| Jan. 10 | |
Morgan State | Memorial Hall | 68-53 DSU | 4-10, 2-1 |
| Jan. 15 | |
North Carolina A&T State | Greensboro, NC | 66-70 NCAT | 4-11, 2-2 |
| Jan. 17 | |
South Carolina State | Orangeburg, SC | 82-73 DSU | 5-11, 3-2 |
| Jan. 22 | |
Hampton | Memorial Hall | 66-64 OT DSU | 6-11, 4-2 |
| Jan. 24 | |
Norfolk State | Memorial Hall | 50-47 DSU | 7-11, 5-2 |
| Jan. 29 | |
Florida A&M | Memorial Hall | 72-50 DSU | 8-11, 6-2 |
| Feb. 01 | |
Bethune-Cookman | Daytona Beach, FL | 63-61 DSU | 9-11, 7-2 |
| Feb. 03 | |
Howard | Memorial Hall | 69-60 DSU | 10-11, 8-2 |
| Feb. 05 | |
Maryland-Eastern Shore | Memorial Hall | 71-45 DSU | 11-11, 9-2 |
| Feb. 12 | |
Coppin State | Baltimore, MD | 71-63 CSU | 11-12, 9-3 |
| Feb. 14 | |
Morgan State | Baltimore, MD | 75-74 MSU | 11-13, 9-4 |
| Feb. 19 | |
North Carolina A&T State | Memorial Hall | 69-59 DSU | 12-13, 10-4 |
| Feb. 21 | |
South Carolina State | Memorial Hall | 67-65 DSU | 13-13, 11-4 |
| Feb. 26 | |
Norfolk State | Norfolk, VA | 72-68 DSU | 14-13, 12-4 |
| Feb. 28 | |
Hampton | Hampton, VA | 64-54 DSU | 15-13, 13-4 |
| Mar. 05 | |
Howard | Washington, DC | 64-57 DSU | 16-13, 14-4 |
| Mar. 09 | MEAC Championship vs. Bethune-Cookman |
Richmond, VA | 66-43 DSU | 17-13, 14-4 | |
| Mar. 11 | MEAC Championship vs. South Carolina State |
Richmond, VA | 61-48 DSU | 18-13, 14-4 | |
| Mar. 12 | MEAC Championship vs. Hampton |
Richmond, VA | 55-53 DSU | 19-13, 14-4 | |
| Mar. 18 | NCAA Championship vs. Duke |
Charlotte, NC | 7:35 |
Indicates
MEAC game. Home games in bold.